The JBRF Genetic Study: The Search and the Strategy
In August of 2003, JBRF funded a major genetic study to search for the genes
that cause early-onset bipolar disorder. The genetic basis of this
psychiatric disorder will yield critical information needed to understand
its impact on the brain's biology. This information will lead to new methods
of treatment that can restore brain function in a way not currently
possible.
The study design chosen by the JBRF researchers is called an "affected sib pair"
strategy. This is a daunting study to do because it requires the
identification of approximately 600 sibling pairs. Typically, this
ascertainment would take a minimum of six years. In the ten months since the
study was announced, JBRF has located more than 400 sib pairs, and is
currently conducting interviews and laying down DNA. To read an FAQ about
this very important study, please click here.
The JBRF Grand Rounds/Expert
Diagnostic Workshop Program
Bipolar disorder was once thought to be rare in children. Now researchers
are discovering that not only can bipolar disorder begin very early in life,
but also that it is much more common than ever imagined. Yet there is
presently no diagnostic criteria that pinpoints how the illness actually
manifests in youngsters. There is no consensus as to core symptoms and
behaviors.
The Juvenile Bipolar Research Foundation has assembled an internationally-recognized
group of over 80 researchers and clinicians to participate in an
online colloquium to foster a consensus as to which symptoms and
behaviors should define the diagnosis of bipolar disorder in children.
To read about this exciting new program click
here.
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